CHILTERN
CHILTERN INTERNATIONAL
HOME | NEWS | EVENTS | PUBLICATIONS | USEFUL LINKS | CAREERS | CONTACT US
Clinical Trials
FIRST IN MAN PHOTOTOXICITY PHASE I-IIa

  Get Paid Participating in Clinical Trials
PUBLICATIONS

Chiltern’s staff have made many contributions to industry scientific publications. The list is divided into 2 categories: publications by CEP’s staff and relevant publications by Professor Ferguson (Spectratox).

New materials will be added on a regular basis, so remember to visit our website and check for updates.


CEP SCIENTIFIC PUBLICATIONS

Biopharm Drug Dispos. 2004 Oct;25(7):303-11.
Pharmacokinetics and safety of oral almotriptan in healthy male volunteers.
McEwen J, Salva M, Jansat JM, Cabarrocas X.

Chiltern (Early Phase) Ltd, Ninewells Hospital and Medical School, Dundee, Scotland.

--------------------------------------------------------------------------------------

Br J Clin Pharmacol. 2004 Jul;58(1):20-5.
Pharmacokinetics of fosfluconazole and fluconazole following multiple intravenous administration of fosfluconazole in healthy male volunteers.
Sobue S, Tan K, Layton G, Eve M, Sanderson JB.

Clinical Pharmacology, Pfizer Global R & D, Tokyo Laboratories, Pfizer Japan Inc., Tokyo, Japan.

--------------------------------------------------------------------------------------

Br J Dermatol. 2003 Dec;149(6):1232-41.
A randomized controlled trial (volunteer study) of sitafloxacin, enoxacin, levofloxacin and sparfloxacin phototoxicity.
Dawe RS, Ibbotson SH, Sanderson JB, Thomson EM, Ferguson J.

Photobiology Unit and DDS Medicines Research Ltd, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, U.K.

--------------------------------------------------------------------------------------

Br J Clin Pharmacol. 2003 Nov;56(5):505-12.
Evaluation of two carrier protein-angiotensin I conjugate vaccines to assess their future potential to control high blood pressure (hypertension) in man.
Downham MR, Auton TR, Rosul A, Sharp HL, Sjostrom L, Rushton A, Richards JP, Mant TG, Gardiner SM, Bennett T, Glover JF.

Protherics plc. (PMD), The Heath Business & Technical Park, Runcorn, UK.

--------------------------------------------------------------------------------------

J Psychopharmacol. 2000 Jun;14(2):164-71.
The acute effects of amisulpride (50 mg and 200 mg) and haloperidol (2 mg) on cognitive function in healthy elderly volunteers.
Legangneux E, McEwen J, Wesnes KA, Bergougnan L, Miget N, Canal M, L'Heritier C, Pinquier JL, Rosenzweig P.

Synthelabo Recherche, Bagneux, France.

--------------------------------------------------------------------------------------

Semin Thromb Hemost. 1999;25 Suppl 2:47-50.
Clopidogrel bioavailability: absence of influence of food or antacids.
McEwen J, Strauch G, Perles P, Pritchard G, Moreland TE, Necciari J, Dickinson JP.

Chiltern (Early Phase) Ltd, Ninewells Hospital and Medical School, Dundee, Scotland, UK.

--------------------------------------------------------------------------------------

Gastroenterol Hepatol. 1999 Apr;22(4):171-5.
[A relative bioavailability study of 2 oral formulations of omeprazole after their administration in repeated doses to healthy volunteers]
Richards JP, Gimeno M, Moreland TA, McEwen J.

Drug Development (Escocia) Ltd., Ninewells Hospital and Medical School, Dundee, Scotland, UK.
--------------------------------------------------------------------------------------

Diabetes Care. 1999 May;22(5):801-5.
Improved postprandial glycemic control with insulin aspart. A randomized double-blind cross-over trial in type 1 diabetes.
Lindholm A, McEwen J, Riis AP.

Novo Nordisk A/S, Bagsvaerd, Denmark.

--------------------------------------------------------------------------------------

J Clin Pharmacol. 1998 Dec;38(12 Suppl):41S-45S.
The effect of food and an antacid on the bioavailability of dexketoprofen trometamol.
McEwen J, De Luca M, Casini A, Gich I, Barbanoj MJ, Tost D, Artigas R, Mauleon D.

Chiltern (Early Phase) Ltd, Ninewells Hospital and Medical School. Dundee.

--------------------------------------------------------------------------------------

Eur Urol. 1998;33(5):481-8.
A double-blind comparison of terazosin and tamsulosin on their differential effects on ambulatory blood pressure and nocturnal orthostatic stress testing.
de Mey C, Michel MC, McEwen J, Moreland T.

ACPS, Mainz-Kastel, Germany.

--------------------------------------------------------------------------------------

Circulation. 1996 May 15;93(10):1860-70.
Systemic endothelin receptor blockade decreases peripheral vascular resistance and blood pressure in humans.
Haynes WG, Ferro CJ, O'Kane KP, Somerville D, Lomax CC, Webb DJ.

Department of Medicine, University of Edinburgh, Western General Hospital, UK.

--------------------------------------------------------------------------------------

Eur J Clin Pharmacol. 1995;48(6):473-7.
Acute safety of the CFC-free propellant HFA-134a from a pressurized metered dose inhaler.
Donnell D, Harrison LI, Ward S, Klinger NM, Ekholm BP, Cooper KM, Porietis I, McEwen J.

Medical Department, 3 M Health Care Ltd., Loughborough, UK.

--------------------------------------------------------------------------------------

Br J Clin Pharmacol. 1993 Jun;35(6):643-7.
Cicaprost, an orally active prostacyclin analogue: its effects on platelet aggregation and skin blood flow in normal volunteers.
Belch JJ, McLaren M, Lau CS, Mackay IR, Bancroft A, McEwen J, Thompson JM.

University Department of Medicine, Ninewells Hospital and Medical School, Dundee.

--------------------------------------------------------------------------------------

Br J Clin Pharmacol. 1992 Oct;34(4):316-21.
Ethanol kinetics: extent of error in back extrapolation procedures.
al-Lanqawi Y, Moreland TA, McEwen J, Halliday F, Durnin CJ, Stevenson IH.

Department of Pharmacology and Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, Dundee.

--------------------------------------------------------------------------------------

Br J Clin Pharmacol. 1991 Sep;32(3):361-6.
The pharmacokinetics of dermatan sulphate MF701 in healthy human volunteers.
Dawes J, McLaren M, Forbes C, Belch JJ, Lane DA, Bray B, McEwen J, Houin G, Gianese F.

Heart Research Institute, Sydney, Australia.

--------------------------------------------------------------------------------------

Br J Clin Pharmacol. 1991 Feb;31(2):200-3.
Magnesium deficiency may be an important determinant of ventricular ectopy in digitalised patients with chronic atrial fibrillation.
Lewis R, Durnin C, McLay J, McEwen J, McDevitt DG.

Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee.

--------------------------------------------------------------------------------------


Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:277-83.
Kinetics of idaverine in healthy male subjects after single dose oral and intravenous administration.
Ebes F, McEwen J, De Vries MH, Raghoebar M.

Department of Drug Disposition, Duphar B.V., Weesp. The Netherlands.

--------------------------------------------------------------------------------------

Br J Clin Pharmacol. 1990 Apr;29(4):455-63.
Comparison of once daily atenolol, nitrendipine and their combination in mild to moderate essential hypertension.
Maclean D, Mitchell ET, Lewis R, Irvine N, McLay JS, McEwen J, Coulson RR, Slater ND, Fitzsimons TJ, McDevitt DG.

University Department of Clinical Pharmacology, Ninewells Hospital, Dundee.

--------------------------------------------------------------------------------------


Eur J Clin Pharmacol. 1990;38(4):379-85.
Pharmacokinetics and pharmacodynamics of the ace inhibitor benazepril hydrochloride in the elderly.
Kaiser G, Ackermann R, Dieterle W, Durnin CJ, McEwen J, Ghose K, Richens A, Holmes IB.

Research and Development Department, CIBA-GEIGY Limited, Basle, Switzerland.

--------------------------------------------------------------------------------------

Biopharm Drug Dispos. 1989 May-Jun;10(3):311-9.
Multiple dose comparison of a whole 240 mg verapamil sustained-release tablet with two half tablets.
Moreland TA, McMurdo ME, McEwen J.

Drug Development (Scotland) Limited, Ninewells Hospital, Dundee.

--------------------------------------------------------------------------------------

Biopharm Drug Dispos. 1989 Jan-Feb;10(1):115-9.
Multiple-dose pharmacokinetics of the new H1-receptor antagonist tazifylline in healthy volunteers.
Bruno R, Jullien I, Auger J, Iliadis A, Dow R, McEwen J, Cano JP, Pinhas H.

Recherche Syntex France, Montlhery.

--------------------------------------------------------------------------------------

Br J Clin Pharmacol. 1989;27 Suppl 2:211S-215S
A pharmacokinetic study of cilazapril in elderly and young volunteers.
Williams PE, Brown AN, Rajaguru S, Walters GE, McEwen J, Durnin C
.
Roche Products Ltd, Welwyn Garden City, Herts.

--------------------------------------------------------------------------------------


Br J Clin Pharmacol. 1989;27 Suppl 2:181S-188S.
The pharmacokinetics and bioavailability of cilazapril in normal man.
Williams PE, Brown AN, Rajaguru S, Francis RJ, Walters GE, McEwen J, Durnin C.

Roche Products Ltd, Welwyn Garden City, Herts.

--------------------------------------------------------------------------------------

J Cardiovasc Pharmacol. 1989;13 Suppl 4:S57-9.
Sustained-release verapamil: multiple-dose pharmacokinetic comparison of 120-mg and 240-mg tablets and the effect of halving a 240-mg tablet.
McEwen J, Durnin C, McMurdo ME, Moreland TA.

Chiltern (Early Phase) Ltd, Ninewells Hospital and Medical School, Dundee, Scotland.

--------------------------------------------------------------------------------------

Diabet Med. 1988 Oct;5(7):671-5.
Improvement in morning hyperglycaemia with basal human ultratard and prandial human actrapid insulin--a comparison of multiple injection regimens.
Davies RR, McEwen J, Moreland TA, Durnin C, Newton RW.

Diabetic Department, Ninewells Hospital and Medical School, Dundee, UK.

--------------------------------------------------------------------------------------

Eur J Drug Metab Pharmacokinet. 1988 Jul-Sep;13(3):201-5.
The effects of once-daily dosing with ranitidine and cimetidine on theophylline pharmacokinetics.
McEwen J, McMurdo ME, Moreland TA.

Chiltern (Early Phase) Ltd, Ninewells Hospital and Medical School, Dundee.

--------------------------------------------------------------------------------------

Br J Clin Pharmacol. 1987 Aug;24(2):133-7.
Prolactin response to low dose sulpiride.
McMurdo ME, Howie PW, Lewis M, Marnie M, McEwen J, McNeilly AS.

--------------------------------------------------------------------------------------

Br J Clin Pharmacol. 1986 Nov;22(5):565-70.
The effects of food and posture on the pharmacokinetics of a biphasic release preparation of nifedipine.
Challenor V, Waller DG, Gruchy BS, Renwick AG, George CF, McMurdo ET, McEwen J.

--------------------------------------------------------------------------------------


Xenobiotica. 1985 Jul;15(7):623-31.
Correlation of the clinical pharmacodynamics of loprazolam with serum concentration.
Stevens LA, Pidgen AW, Bevan CD, Ings RM, Lawrence JR, McEwen J.

--------------------------------------------------------------------------------------

J Pharm Pharmacol. 1984 Nov;36(11):734-9
The effect of in-vivo dispersion and gastric emptying on glibenclamide absorption from a novel, rapidly dissolving capsule formulation.
Ganley JA, McEwen J, Calvert RT, Barker MC.

--------------------------------------------------------------------------------------

J Pharm Sci. 1984 Apr;73(4):437-41.
Comparative bioavailability of two furosemide formulations in humans.
Martin BK, Uihlein M, Ings RM, Stevens LA, McEwen J.

RELEVANT PUBLICATIONS

--------------------------------------------------------------------------------------

Kerr A, Woods J, Ferguson J.  Photocontact allergic and phototoxic studies of chlorproethazine.  Photodermatology, Photoimmunology, Photomedicine 2008; 24: 11-15.
-------------------------------------------------------------------------------------

Ferguson J, DeLeo VA.  Drug and chemical photosensitivity: exogenous.  In: Photodermatology.  Lim HW, Honigsmann H, Hawk JLM (eds).  Informa Healthcare, New York, 2007.
--------------------------------------------------------------------------------------

Ferguson J.  Drug-induced photosensitivity.  In: Photodermatology.  Ferguson J, Dover J, eds.  2006, Chapter 12, pp66-71.
--------------------------------------------------------------------------------------

Dawe RS, Ibbotson SH, Sanderson JB, Thomson EM, Ferguson J.  A randomised controlled trial (volunteer study) of sitafloxacin, enoxacin, levofloxacin and sparfloxacin phototoxicity.  British Journal of Dermatology 2003; 149: 1232-1241.
--------------------------------------------------------------------------------------

Ferguson J.  Phototoxicity due to fluoroquinolones.  Chapter 28 in Hooper DC, Rubinstein E,  Quinolone Antimicrobial Agents, 3rd edition.  ASM   Press, Washington, D.C., 2003, pp449-458.
--------------------------------------------------------------------------------------

Ferguson J, McEwen J, Al-Ajmi H, Purkins L, Colman PJ, Willavize SA.  A comparison of the photosensitizing potential of trovafloxacin with that of other quinolones in healthy subjects.  Journal of Antimicrobial Chemotherapy  2000; 45: 503-509.
--------------------------------------------------------------------------------------

Traynor NJ, Barrat MD, Lovell WW, Ferguson J, Gibbs NK.  Comparison of an in vitro cellular phototoxicity model against controlled clinical trials of fluoroquinolone skin phototoxicity.  Toxicology in vitro 2000; 14: 275-283.
--------------------------------------------------------------------------------------

Man I, Murphy J, Ferguson J.  Fluoroquinolone phototoxicity:  a comparison of moxifloxacin and lomefloxacin in normal volunteers. Journal of Antimicrobial Chemotherapy 1999; 43, Suppl. B: 77-82.
--------------------------------------------------------------------------------------

Man I, Traynor NJ, Ferguson J.  Recent developments in fluoroquinolone photoxicity.  Photodermatology, Photoimmunology, Photomedicine1999; 15: 32-33.
--------------------------------------------------------------------------------------

Ferguson J.  Fluoroquinolones phototoxicity - Moxifloxacin in context.  In: Proceedings of the First International Moxifloxacin Symposium.  Mandell   L. (ed).  Springer Verlag, Berlin, 1999, pp
--------------------------------------------------------------------------------------

Ferguson J.  Drug and chemical photosensitivity.  Chapter in:  Photodermatology.  Hawk JLM (ed). London, Arnold Publishers 1999, pp155-169.
--------------------------------------------------------------------------------------

Vousden M, Ferguson J, Richards J, Bird N, Allen A.  Evaluation of phototoxic potential of gemifloxacin in healthy volunteers compared with ciprofloxacin.  Chemotherapy 1999; 45: 512-520.
--------------------------------------------------------------------------------------

Ferguson J, McEwen J, Gohler K, Mignot A, Watson D.  Phototoxic potential of gatifloxacin, a new fluoroquinolone antimicrobial.  Drugs 1999; 58, Suppl: 397-399.
--------------------------------------------------------------------------------------

Ferguson J, Dawe R.  Phototoxicity in quinolones:  comparison of ciprofloxacin and grepafloxacin.  Journal of Antimicrobial Chemotherapy 1997; 40, Suppl. A, 93-98.
--------------------------------------------------------------------------------------
                                                                                                 
Ferguson J.  Fluoroquinolone photosensitization:  A review of clinical and laboratory studies.  Photochemistry and Photobiology 1995; 62: 954-958.
--------------------------------------------------------------------------------------

Ferguson J, Johnson BE. Clinical and laboratory studies of the photosensitizing potential of norfloxacin, a 4-quinolone broad spectrum antibiotic. British Journal of Dermatology 1993, 128, 285-295.
--------------------------------------------------------------------------------------

Ferguson J, Johnson BE. Ciprofloxacin-induced photosensitivity: in vitro and in vivo studies. British Journal of Dermatology 1990 123, 9-20.
--------------------------------------------------------------------------------------

Johnson BE, Ferguson J. Drug and chemical photosensitivity. Seminars in Dermatology 1990, 9, 39-46.
--------------------------------------------------------------------------------------

Print This Page | Disclaimer